Note:

The genetic defect in the MDR1 gene may become life threatening as soon as affected animals need medication. It is very important for owners (especially of dogs of Collie breeds and of crossbred dogs related to Collies) to make sure what the genetic status of their dog is and, in consultation with the veterinarian, to check the page on "dangerous drugs".
In time we are probably going to find in dogs more than the one known genetic disorder with clinical symptoms comparable to the ones of the MDR1 defect. The research group of Dr. Katrina Mealey at the Department of Veterinary Clinical Sciences of Washington State University and several other researchers all over the world are searching for causes and solutions. Through our website we will keep you informed about new developments on neurotoxic and other genetic disorders.