|
|
A DNA test for Multidrug Resistance (MDR1) in Collies.
What is MDR1?
A DNA test for MDR1
"Dangerous drugs" for oversensitive dogs
In literature a range of drugs that can cause oversensitivity reactions in
dogs (especially in Collie breeds) is reported. Whenever an animal suffering
from the genetic disorder needs medication, the latest version of the
"dangerous drugs" list should be checked. It is likely this list will grow to
include more drugs as research progresses. Biochemical studies have shown
that the MDR1 gene has the potential to act on over 50 different drugs.
The Veterinary Clinical Pharmacology Laboratory (VCPL), College of Veterinary
Medicine of Washington State University publishes the latest developments in
pharmacologic research regarding the defect in Multidrug Resistance on its
website.
Before administering drugs always check the VCPL webpage first for updates in
order to be informed on the latest developments:
http://www.vetmed.wsu.edu/depts-VCPL/#Drugs
The list of December 1st, 2005 includes the Problem Drugs, the drugs
that have been documented, or are strongly suspected to cause problems in dogs
with the MDR1 mutation:
| Acepromazine | | (tranquilliser) |
| Butorphanol | | (pain control) |
| Cyclosporin | | (immunosuppressive agent) |
| Digoxin | | (heart drug, controls rate and rhythm of the heartbeat) |
| Doxorubicin | | (anticancer agent) |
| Ivermectin | | (antiparasitic agent) |
| Loperamide | | (Imodium ®; antidiarrheal agent) |
| Vinblastine | | (anticancer agent) |
| Vincristine | | (anticancer agent) |
and the Potential Problem Drugs, the drugs that may potentially cause problems
when given to dogs that have the MDR1 mutation:
| Domperidone | | (stimulation of stomac activity) |
| Etoposide | | (anticancer agent) |
| Mitoxantrone | | (anticancer agent) |
| Morphine | | (tranquilliser, pain control) |
| Ondansetron | | (prevents nausea and vomiting) |
| Paclitaxe | | (anticancer agent) |
| Quinidine | | (anti-arrhytmic heart drug) |
| Rifampicin | | (antibiotic) |
in the European literature a few more drugs are added to the list of Problem Drugs:
| Chinidin | | (heart drug) |
| Dexamethasone | | (anti-inflammation, against allergic reactions) |
| Ebastine | | (against allergic reactions) |
| Grepafloxacin, Sparfloxacin | | (antibiotics) |
Breeds at risk
Breeding policy
Testing for MDR1
|
|