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A DNA test for L2-HGA in Staffordshire Bull Terriers.
What is L2-HGA?
L2-HGA (L2-hydroxyglutaric aciduria) in Staffordshire Bull Terriers
is a neurometabolic disorder characterised by elevated levels of
L2-hydroxyglutaric acid in urine, plasma and cerebrospinal fluid. In the past
few years a number of Staffords have been diagnosed with this metabolic disorder.
L2-HGA affects the central nervous system, with clinical signs usually
apparent between six months and one year (although they can appear later).
The condition manifests itself in varied ways with dogs exhibiting behaviour
changes and dementia (staring at walls, getting stuck under tables and in
corners, loss of obedience and house training), anxiety states, having
full-blown epileptic seizures, as well as exercise intolerance, ataxia
(unsteady gait), tremors and muscular stiffness as a result of exercise or
excitement. Dogs from differing bloodlines have been found to be affected
and the number of affected dogs diagnosed has risen.
DNA test for L2-HGA
Breeds at risk
Breeding policy
Testing for L2-HGA
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