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A DNA test for CaniAne Leukocyte Adhesion Deficiency (CLAD)
What is CLAD?
A DNA test for CLAD
In literature CLAD has been reported in Irish Setters and in Irish Red
and White Setters. The disorder is inherited as an autosomal recessive trait.
In other words, affected animals of those breeds have two mutant genes, one
inherited from each parent. Carriers have only one mutant gene and do not show
clinical signs.
Applying the DNA test allows breeders to classify their potential breeding
animals at a young age as genetically healthy ("clear"), "carrier" or "affected"
in order to select effectively against the genetic disorder.
The CLAD DNA test yields three possible outcomes:
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Your dog is clear (and has two healthy alleles: CLAD/CLAD), it will not suffer
from oversensitivity for infections and, just as important, it will not pass
on the defect (the defective allele) to the next generation.
-
Your dog is a carrier (and has one healthy allele and one defective one: CLAD/clad),
it will not suffer from CLAD but it will pass on the defective allele to
half of its offspring.
-
Your dog is affected (and has two defective alleles: clad/clad), it will pass
on the defective allele to all of its offspring in the next generation and it will
be expected to experience the disadvantages of the immunodeficiency. So it is
one of the animals that will suffer from CLAD.
Breeds at risk
Breeding policy
Testing for CLAD
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